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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">NOD2</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_NOD2_protein" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
<tbody><tr>
<th colspan="3" style="background:#90EE90; color:#202122;">NOD2 protein
</th></tr>
<tr>
<td>Andere Namen
</td>
<td colspan="2">
<p>Nod2b, CARD15
</p>
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
</th></tr>
<tr>
<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
</td>
<td colspan="2" style="text-align:center;">1.040 <a href="Aminos%C3%A4uren" title="Aminosäuren">Aminosäuren</a>, 115.283 <a href="Atomare_Masseneinheit" title="Atomare Masseneinheit">Da</a>
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
</th></tr>
<tr>
<td><a href="Human_Genome_Organisation" title="Human Genome Organisation">Gen-Name</a>
</td>
<td colspan="2" class="" style="text-align:center;"><i><a rel="nofollow" class="external text" href="https://www.genenames.org/tools/search/#!/all?query=5331">NOD2</a></i>
</td></tr>
<tr>
<td>Externe IDs
</td>
<td colspan="2" class="">
<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=NOD2">NOD2</a></li>
<li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/605956">605956</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q9HC29">Q9HC29</a></li></ul>
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
</th></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
</td>
<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=Q9HC29">Hovergen</a>
</td></tr>
<tr>
<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;">
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Maus
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=64127&rn=1">64127</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=257632&rn=1">257632</a></span>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Ensembl" title="Ensembl">Ensembl</a>
</td>
<td><span class=""><small><small><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000167207;db=core">ENSG00000167207</a></small></small></span>
</td>
<td>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/D6CHF9">D6CHF9</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q8K3Z0">Q8K3Z0</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (mRNA)
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001293557.1">NM_001293557.1</a>
</td>
<td>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="National_Center_for_Biotechnology_Information" title="National Center for Biotechnology Information">Refseq</a> (Protein)
</td>
<td><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001280486.1">NP_001280486.1</a>
</td>
<td>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Genlocus" title="Genlocus">Genlocus</a>
</td>
<td>
</td>
<td>
</td></tr>
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<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=64127">64127</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=257632">257632</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p>Das <a href="Protein" title="Protein">Protein</a> <b>NOD2</b> ist ein <a href="Rezeptor_(Biochemie)" title="Rezeptor (Biochemie)">Rezeptor</a> für Fremdstoffe im <a href="Angeborene_Immunantwort" title="Angeborene Immunantwort">angeborenen Immunsystem</a> der <a href="S%C3%A4ugetiere" title="Säugetiere">Säugetiere</a>, ein so genannter <a href="Pattern-Recognition_Receptor" class="mw-redirect" title="Pattern-Recognition Receptor">Pattern-Recognition Receptor</a>. NOD2 wird hauptsächlich von <a href="Monozyt" title="Monozyt">Monozyten</a><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>, Dendritischen Zellen<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> und intestinalen Epithelzellen<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> produziert, erkennt insbesondere das <a href="Bakteriell" class="mw-redirect" title="Bakteriell">bakterielle</a> <a href="Muramyl-Dipeptid" title="Muramyl-Dipeptid">Muramyl-Dipeptid</a> und startet nach der Erkennung der Fremdstoffe über RICK und IKK-gamma den <a href="NF-Kappa-B" class="mw-redirect" title="NF-Kappa-B">NF-Kappa-B</a>-<a href="Signalweg" class="mw-redirect" title="Signalweg">Signalweg</a>. <a href="Mutation" title="Mutation">Mutationen</a> im <i>NOD2</i>-<a href="Gen" title="Gen">Gen</a> sind für die seltenen Erbkrankheiten <a href="Blau-Syndrom" title="Blau-Syndrom">Blau-Syndrom</a> und früh beginnende <a href="Sarkoidose" title="Sarkoidose">Sarkoidose</a> (EOS) verantwortlich, sowie für erhöhtes Risiko, an <a href="Colitis_ulcerosa" title="Colitis ulcerosa">Colitis ulcerosa</a> oder <a href="Morbus_Crohn" title="Morbus Crohn">Morbus Crohn</a> zu erkranken.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Weiterhin verdoppelt das Vorliegen von Mutationen im <i>NOD2</i>-Gen das Risiko nach einer Knochenmarks- oder Blutstammzelltransplantation an einer Darm-<a href="Graft-versus-Host-Reaktion" title="Graft-versus-Host-Reaktion">Graft-versus-Host-Reaktion</a> zu erkranken. Tragen sowohl der Knochenmarks-Spender als auch der Knochenmarks-Empfänger Mutationen im <i>NOD2</i>-Gen addiert sich das Risiko.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>
</p><p>Neuere Erkenntnisse deuten darauf hin, dass NOD2 neben bakteriellen auch virale Muster erkennt und als Folge über MAVS und IRF3 die virale Immunantwort aktiviert. Zusammen mit NOD1 ist NOD2 damit ein zentraler Bestandteil des angeborenen Immunsystems.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>
<ul><li>Y. Ogura, N. Inohara u. a.: <i>Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.</i> In: <i><a href="The_Journal_of_biological_chemistry" class="mw-redirect" title="The Journal of biological chemistry">The Journal of biological chemistry</a>.</i> Band 276, Nummer 7, Februar 2001, S. 4812–4818, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220021-9258%22&key=cql">0021-9258</a></span></span>. <a href="https://doi.org/10.1074/jbc.M008072200" class="extiw external" title="doi:10.1074/jbc.M008072200">doi:10.1074/jbc.M008072200</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11087742?dopt=Abstract">PMID 11087742</a>.</li>
<li>O. Gutierrez, C. Pipaon, N. Inohara u. a.: <i>Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation.</i> In: <i>The Journal of Biological Chemistry.</i> 277(44), November 2002, S. 41701–41705. <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220021-9258%22&key=cql">0021-9258</a></span></span>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/12194982?dopt=Abstract">PMID 12194982</a>.</li>
<li>J. Hampe, A. Cuthbert, P. J. Croucher, M. M. Mirza, S. Mascheretti, S. Fisher, H. Frenzel, K. King, A. Hasselmeyer, A. J. MacPherson, S. Bridger, S. van Deventer, A. Forbes, S. Nikolaus, J. E. Lennard-Jones, U. R. Foelsch, M. Krawczak, C. Lewis, S. Scheiber, C. G. Mathew: <i>Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations.</i> In: <i>Lancet.</i> 357(9272), 16. Jun 2001, S. 1925–1928. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11425413?dopt=Abstract">PMID 11425413</a>.</li>
<li>P. Rosenstiel, M. Fantini, K. Bräutigam u. a.: <i>TNF-alpha and IFN-gamma regulate the expression of NOD2(CARD15) gene in human intestinal epithelial cells.</i> In: <i>Gastroenterology.</i> 124, 2003, S. 1001–1009. <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220016-5085%22&key=cql">0016-5085</a></span></span>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/12671897?dopt=Abstract">PMID 12671897</a>.</li>
<li>A. G. Kutikhin: <i>Role of NOD1/CARD4 and NOD2/CARD15 gene polymorphisms in cancer etiology.</i> In: <i>Human immunology.</i> Band 72, Nummer 10, Oktober 2011, S. 955–968, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221879-1166%22&key=cql">1879-1166</a></span></span>. <a href="https://doi.org/10.1016/j.humimm.2011.06.003" class="extiw external" title="doi:10.1016/j.humimm.2011.06.003">doi:10.1016/j.humimm.2011.06.003</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/21745515?dopt=Abstract">PMID 21745515</a>. (Review).</li>
<li>L. Le Bourhis, S. Benko, S. E. Girardin: <i>Nod1 and Nod2 in innate immunity and human inflammatory disorders.</i> In: <i><a href="Biochemical_Society_transactions" class="mw-redirect" title="Biochemical Society transactions">Biochemical Society transactions</a>.</i> Band 35, Pt 6, Dezember 2007, S. 1479–1484, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220300-5127%22&key=cql">0300-5127</a></span></span>. <a href="https://doi.org/10.1042/BST0351479" class="extiw external" title="doi:10.1042/BST0351479">doi:10.1042/BST0351479</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/18031249?dopt=Abstract">PMID 18031249</a>. (Review).</li>
<li>P. Rosenstiel, S. Schreiber: <i>NOD-like receptors–pivotal guardians of the immunological integrity of barrier organs.</i> In: <i><a href="Advances_in_Experimental_Medicine_and_Biology" title="Advances in Experimental Medicine and Biology">Advances in Experimental Medicine and Biology</a>.</i> Band 653, 2009, S. 35–47, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220065-2598%22&key=cql">0065-2598</a></span></span>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/19799110?dopt=Abstract">PMID 19799110</a>. (Review).</li>
<li>T. D. Kanneganti, M. Lamkanfi, G. Núñez: <i>Intracellular NOD-like receptors in host defense and disease.</i> In: <i>Immunity.</i> Band 27, Nummer 4, Oktober 2007, S. 549–559, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221074-7613%22&key=cql">1074-7613</a></span></span>. <a href="https://doi.org/10.1016/j.immuni.2007.10.002" class="extiw external" title="doi:10.1016/j.immuni.2007.10.002">doi:10.1016/j.immuni.2007.10.002</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17967410?dopt=Abstract">PMID 17967410</a>. (Review).</li>
<li>K. Geddes, J. G. Magalhães, S. E. Girardin: <i>Unleashing the therapeutic potential of NOD-like receptors.</i> In: <i><a href="Nature_Reviews_Drug_Discovery" title="Nature Reviews Drug Discovery">Nature Reviews Drug Discovery</a>.</i> Band 8, Nummer 6, Juni 2009, S. 465–479, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221474-1784%22&key=cql">1474-1784</a></span></span>. <a href="https://doi.org/10.1038/nrd2783" class="extiw external" title="doi:10.1038/nrd2783">doi:10.1038/nrd2783</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/19483708?dopt=Abstract">PMID 19483708</a>. (Review).</li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">Y. Ogura, N. Inohara, A. Benito, F. F. Chen, S. Yamaoka, G. Nunez: <i>Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.</i> In: <i>The Journal of biological chemistry.</i> Band 276, Nummer 7, Februar 2001, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220021-9258%22&key=cql">0021-9258</a></span></span>, S. 4812–4818, <a href="https://doi.org/10.1074/jbc.M008072200" class="extiw external" title="doi:10.1074/jbc.M008072200">doi:10.1074/jbc.M008072200</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11087742?dopt=Abstract">PMID 11087742</a>.</span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">O. Gutierrez, C. Pipaon, N. Inohara, A. Fontalba, Y. Ogura, F. Prosper, G. Nunez, J. L. Fernandez-Luna: <i>Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation.</i> In: <i>The Journal of biological chemistry.</i> Band 277, Nummer 44, November 2002, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220021-9258%22&key=cql">0021-9258</a></span></span>, S. 41701–41705, <a href="https://doi.org/10.1074/jbc.M206473200" class="extiw external" title="doi:10.1074/jbc.M206473200">doi:10.1074/jbc.M206473200</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/12194982?dopt=Abstract">PMID 12194982</a>.</span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">P. Rosenstiel, M. Fantini, K. Bräutigam, T. Kühbacher, G. H. Waetzig, D. Seegert, S. Schreiber: <i>TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.</i> In: <i>Gastroenterology.</i> Band 124, Nummer 4, April 2003, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220016-5085%22&key=cql">0016-5085</a></span></span>, S. 1001–1009, <a href="https://doi.org/10.1053/gast.2003.50157" class="extiw external" title="doi:10.1053/gast.2003.50157">doi:10.1053/gast.2003.50157</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/12671897?dopt=Abstract">PMID 12671897</a>.</span>
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<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text"><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/Q9HC29">Q9HC29</a></span>
</li>
<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">E. Holler, G. Rogler, H. Herfarth, J. Brenmoehl, P. J. Wild, J. Hahn, G. Eissner, J. Schoelmerich, R. Andreesen: <i>Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation.</i> In: <i>Blood.</i> Band 104, Nummer 3, 2004, S. 889–894, <a href="https://doi.org/10.1182/blood-2003-10-3543" class="extiw external" title="doi:10.1182/blood-2003-10-3543">doi:10.1182/blood-2003-10-3543</a>.</span>
</li>
<li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text">K. Landfried, F. Bataille, G. Rogler, J. Brenmoehl, K. Kosovac, D. Wolff, I. Hilgendorf, J. Hahn, M. Edinger, P. Hoffmann, F. Obermeier, J. Schoelmerich, R. Andreesen, E. Holler: <i>Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease.</i> In: <i>Clinical and Experimental Immunology.</i> Band 159, Nummer 1, 2010, S. 87–92, <a href="https://doi.org/10.1111/j.1365-2249.2009.04049.x" class="extiw external" title="doi:10.1111/j.1365-2249.2009.04049.x">doi:10.1111/j.1365-2249.2009.04049.x</a>.</span>
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<li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text">A. Sabbah, T. H. Chang u. a.: <i>Activation of innate immune antiviral responses by Nod2.</i> In: <i><a href="Nature_Immunology" title="Nature Immunology">Nature Immunology</a>.</i> Band 10, Nummer 10, Oktober 2009, S. 1073–1080, <span class="-print"><a href="Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221529-2916%22&key=cql">1529-2916</a></span></span>. <a href="https://doi.org/10.1038/ni.1782" class="extiw external" title="doi:10.1038/ni.1782">doi:10.1038/ni.1782</a>. <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/19701189?dopt=Abstract">PMID 19701189</a>. <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752345/">PMC 2752345</a> (freier Volltext).</span>
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